Chemotherapy is useful for bladder cancer, but there are many bladder cancer chemotherapy options, and the effect is different for patients with different stages. For patients with non-muscle invasive bladder cancer (the earliest stage of bladder cancer), systemic chemotherapy is not required. After the tumor is removed (transurethral resection of the bladder tumor or partial bladder resection of the open surgery), chemotherapy drugs are infused into the bladder Doing local chemotherapy can prevent recurrence and does not require systemic chemotherapy.

Intravesical chemotherapeutic drugs are rarely absorbed into the bloodstream, so there is no or little systemic toxicity or side effects, but bladder irritation symptoms (referring to frequent urination, urgency, dysuria, and endless urination) are common.
　　 For bladder cancer that invades the muscular layer of the bladder (that is, muscular invasive bladder cancer), intravesical infusion chemotherapy is basically useless. Radical cystectomy and urinary diversion are generally required. Diffusion, supplemented with systemic chemotherapy to prevent recurrence and metastasis. If you want to keep the bladder, you must use chemotherapy and radiotherapy together to control the tumor. About 70% of the bladder is successfully preserved, and 30% of the tumor cannot be controlled. You need to perform salvage total cystectomy.
　　For patients with metastatic bladder cancer, although systemic combined chemotherapy can be used, the effective rate reaches 70％, but the average survival time is only 11 months, and 90％ patients die within 5 years.
　　Our clinical observation found that locally advanced bladder cancer (T3-4, or pelvic lymph node metastasis) applied 2 courses of arterial chemotherapy after radical cystectomy can prevent postoperative tumor recurrence and metastasis, 5 years The overall survival rate was 56.7％, and the 5-year overall survival rate of patients without surgery alone was only 24.1％ A randomized clinical comparative study is now underway to further determine the role of adjuvant arterial chemotherapy in preventing tumor recurrence and metastasis after radical cystectomy. Patients with locally advanced bladder cancer are welcome to participate in treatment and research.